Story of an infection: Viral dynamics and host responses in the <i>Caenorhabditis elegans</i>-Orsay virus pathosystem.

ABSTRACT: Orsay virus (OrV) is the only known natural virus affecting Caenorhabditis elegans, with minimal impact on the animal's fitness due to its robust innate immune response. This study aimed to understand the interactions between C. elegans and OrV by tracking the infection's progression during larval development. Four distinct stages of infection were identified on the basis of viral load, with a peak in capsid-encoding RNA2 coinciding with the first signs of viral egression. Transcriptomic analysis revealed temporal changes in gene expression and functions induced by the infection. A specific set of up-regulated genes remained active throughout the infection, and genes correlated and anticorrelated with virus accumulation were identified. Responses to OrV mirrored reactions to

SUBMITTER: Castiglioni VG 

PROVIDER: S-EPMC11430451 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature