Adverse Obstetric Outcomes after Breast Cancer Diagnosis: An Observational Database Study in Germany.

ABSTRACT:

Background/objectives

Breast cancer may negatively affect later pregnancy and childbirth. We aimed to analyze the impact of previous breast cancer on obstetric outcomes in postdiagnosis pregnancies.

Methods

Insurance claims data in Southern Germany were used to identify breast cancer (BC) survivors with at least one subsequent delivery after cancer diagnosis between 2010 and 2020. In total, 74 BC survivors were compared to 222 age-matched controls with frequency matching on their age at their postdiagnosis delivery.

Results

Endocrine therapy was associated with a significantly lower probability of birth compared to BC survivors without endocrine therapy (HR 0.36; 95% CI 0.18-0.53; p < 0.0001). The risks of preterm birth, low birth weight (LBW), gestational diab

SUBMITTER: Scholz AS 

PROVIDER: S-EPMC11430513 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature