Comprehensive analysis of the cerebrospinal fluid and serum metabolome in neurological diseases.

ABSTRACT:

Background

Comprehensive characterization of the metabolome in cerebrospinal fluid (CSF) and serum by Nuclear Magnetic Resonance (NMR) spectroscopy may identify biomarkers and contribute to the understanding of the pathophysiology of neurological diseases.

Methods

Metabolites were determined by NMR spectroscopy in stored CSF/serum samples of 20 patients with Parkinson's disease, 25 patients with other neuro-degenerative diseases, 22 patients with cerebral ischemia, 48 patients with multiple sclerosis, and 58 control patients with normal CSF findings. The data set was analysed using descriptive and multivariate statistics, as well as machine learning models.

Results

CSF glucose and lactic acid measured by NMR spectroscopy and routine clinical chemistry showed a strong

SUBMITTER: Otto C 

PROVIDER: S-EPMC11430517 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature