The anticancer potential of tetrahydrocurcumin-phytosomes against oral carcinoma progression.

ABSTRACT:

Background

Herbal medicine combined with nanotechnology offers an alternative to the increasing burden of surgery and/or chemotherapy, the main therapeutics of oral carcinoma. Phytosomes are nano-vesicular systems formed by the interaction between phospholipids and phyto-active components via hydrogen bonding, exhibiting superior efficacy over pure phytocomponents in drug delivery.

Methods

Tetrahydrocurcumin (THC)-phytosomes were prepared by thin film hydration method. After characterization, in vitro cytotoxicity, antiproliferative capacity, antioxidant potential and full apoptotic workup were paneled on oral squamous cell carcinoma (SCC4) in comparison with native THC-solution and cisplatin (3.58 µg/mL intravenous injection), as positive controls. In addition, we tested th

SUBMITTER: Raouf N 

PROVIDER: S-EPMC11430579 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature