Advanced Liver-on-a-Chip Model for Evaluating Drug Metabolism and Hepatotoxicity.

ABSTRACT: The liver has many important functions, including the biotransformation of drugs and detoxification of the human organism. As such, it is also exposed to many harmful substances, which leads to disorders and diseases such as cirrhosis. For these reasons, it seems important to consider liver metabolism and the direct effects on the liver when evaluating the efficacy of new drugs. Accordingly, we have developed an advanced in vitro liver model using an organ-on-a-chip approach that replicates many of the morphological and functional features of the liver in vivo. The model we created can metabolize drugs, which we demonstrated using two widely used anticancer drugs, 5-fluorouracil (5FU) and capecitabine (CAP). In addition, to the best of our knowledge, we are the first who evaluate the direc

SUBMITTER: Frojdenfal S 

PROVIDER: S-EPMC11430604 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature