UCN-Centric Prognostic Model for Predicting Overall Survival and Immune Response in Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC), a prevalent malignancy, ranks third in global incidence and second in mortality rates. Despite advances in screening methods such as colonoscopy, the accurate diagnosis of CRC remains challenging due to the absence of reliable biomarkers. This study aimed to develop a robust prognostic model for precise CRC outcome prediction. Employing weighted co-expression network analysis (WGCNA) and Cox regression analysis on data from The Cancer Genome Atlas (TCGA), we identified a panel of 12 genes strongly associated with patient survival. This gene panel facilitated accurate CRC outcome predictions, which is also validated via the external validation cohort GSE17536. We conducted further investigations into the key gene, urocortin (UCN), using single-cell tra

SUBMITTER: Liu J 

PROVIDER: S-EPMC11430869 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature