Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches.

ABSTRACT: Tuberculosis (TB) remains an impactful infectious disease, leading to millions of deaths every year. Mycobacterium tuberculosis causes the formation of granulomas, which will determine, through the host-pathogen relationship, if the infection will remain latent or evolve into active disease. Early TB diagnosis is life-saving, especially among immunocompromised individuals, and leads to proper treatment, preventing transmission. This review addresses different approaches to diagnosing TB, from traditional methods such as sputum smear microscopy to more advanced molecular techniques. Integrating these techniques, such as polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP), has significantly improved the sensitivity and specificity of M. tuberculosis

SUBMITTER: Bartolomeu-Goncalves G 

PROVIDER: S-EPMC11430992 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature