A Variant-Centric Analysis of Allele Sharing in Dogs and Wolves.

ABSTRACT: Canines are an important model system for genetics and evolution. Recent advances in sequencing technologies have enabled the creation of large databases of genetic variation in canines, but analyses of allele sharing among canine groups have been limited. We applied GeoVar, an approach originally developed to study the sharing of single nucleotide polymorphisms across human populations, to assess the sharing of genetic variation among groups of wolves, village dogs, and breed dogs. Our analysis shows that wolves differ from each other at an average of approximately 2.3 million sites while dogs from the same breed differ at nearly 1 million sites. We found that 22% of the variants are common across wolves, village dogs, and breed dogs, that ~16% of variable sites are common across breed do

SUBMITTER: Funk MW 

PROVIDER: S-EPMC11431226 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature