Co-Occurrence of Two Plasmids Encoding Transferable bla_NDM-1 and tet(Y) Genes in Carbapenem-Resistant Acinetobacter bereziniae.

ABSTRACT: Acinetobacter bereziniae has emerged as a significant human pathogen, acquiring multiple antibiotic resistance genes, including carbapenemases. This study focuses on characterizing the plasmids harboring the bla_NDM-1 and tet(Y) genes in two carbapenem-resistant A. bereziniae isolates (UCO-553 and UCO-554) obtained in Chile during the COVID-19 pandemic. Methods: Antibiotic susceptibility testing was conducted on UCO-553 and UCO-554. Both isolates underwent whole-genome sequencing to ascertain their sequence type (ST), core genome multilocus sequence-typing (cgMLST) profile, antibiotic resistance genes, plasmids, and mobile genetic elements. Conjugation experiments were performed for both isolates. Results: Both isolates exhibited broad re

SUBMITTER: Opazo-Capurro A 

PROVIDER: S-EPMC11431271 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature