In Vivo Tissue Distribution and Pharmacokinetics of FITC-Labelled Hizikia fusiforme Polyphenol-Polysaccharide Complex in Mice.

ABSTRACT: In this study, a quantitative method based on fluorescein isothiocyanate (FITC)-labelled Hizikia fusiforme polyphenol-polysaccharide complex (HPC) and its purified fractions (PC1, PC4) was used, and its pharmacokinetics and tissue distribution were investigated in mice. The results showed that the FITC-labelled method had good linearity (R² > 0.99), intra-day and inter-day precision (RSD, %) consistently lower than 15%, recovery (93.19-106.54%), and stability (RSD < 15%), which met the basic criteria for pharmacokinetic studies. The pharmacokinetic and tissue distribution results in mice after administration showed that all three sample groups could enter the blood circulation. and HPC-FITC had a longer half-life (T_1/2: 26.92 ± 0.76 h) and mean retention time (

SUBMITTER: Li Y 

PROVIDER: S-EPMC11431462 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature