CO₂ Breathing Prior to Simulated Diving Increases Decompression Sickness Risk in a Mouse Model: The Microbiota Trail Is Not Forgotten.

ABSTRACT: Decompression sickness (DCS) with neurological disorders is the leading cause of major diving accidents treated in hyperbaric chambers. Exposure to high levels of CO₂ during diving is a safety concern for occupational groups at risk of DCS. However, the effects of prior exposure to CO₂ have never been evaluated. The purpose of this study was to evaluate the effect of CO₂ breathing prior to a provocative dive on the occurrence of DCS in mice. Fifty mice were exposed to a maximum CO₂ concentration of 70 hPa, i.e., 7% at atmospheric pressure, for one hour at atmospheric pressure. Another 50 mice breathing air under similar conditions served as controls. In the AIR group (control), 22 out of 50 mice showed post-dive symptoms compared to 44 out of 50

SUBMITTER: Daubresse L 

PROVIDER: S-EPMC11431549 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature