Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists.

ABSTRACT: The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, and therefore represents a promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with improved pharmacology and potency may prove useful in the development of Th17-mediated adaptive immune responses. Herein, we report on in vitro and in silico investigations of specific Mincle ligand-receptor interactions required for the effective receptor engagement and activation of Th17-polarizing cytokines. Specifically, we employed a library of trehalose benzoate scaffolds, varying the degree of aryl lipidation and regiochemistry that produce inflammatory cytokines in a Mincle-dependent fashion. In vitro interleukin-6 (IL-6) cytokine production by hum

SUBMITTER: Riel AMS 

PROVIDER: S-EPMC11432005 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature