Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.

ABSTRACT:

Objective

To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, cardiovascular (CV) mortality, and cancer mortality.

Patients and methods

We analyzed data from UK Biobank, which included 117,702 subjects with baseline plasma DHA levels and 12.7 years of follow-up between April 2007 and December 2021. Associations with risk for mortality endpoints were analyzed categorically by quintile of DHA plasma levels.

Results

Comparing the lowest to highest quintiles of circulating levels of DHA, there was 21% lower risk of all-cause mortality (HR, 0.79; 95% CI, 0.74 to 0.85; P<.0001). In a secondary analysis, we merged the UK Biobank findings with those from a recent FORCE (Fatty Acid and Outcome Research Cons

SUBMITTER: O'Keefe EL 

PROVIDER: S-EPMC11432052 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature