Hepatic Proteomic Changes Associated with Liver Injury Caused by Alcohol Consumption in <i>Fpr2^-</i>^/<i>-</i> Mice.

ABSTRACT: Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes contributing to ALD have been elucidated, a complete understanding of the underlying mechanisms is still lacking. The current study employed a proteomic approach to identify hepatic changes resulting from ethanol (EtOH) consumption and the genetic ablation of the formyl peptide receptor 2 (FPR2), a G-protein coupled receptor known to regulate multiple signaling pathways and biological processes, in a mouse model of ALD. Since previous research from our team demonstrated a notable reduction in hepatic FPR2 protein levels in patients with alcohol-associated hepatitis (AH), the proteomic changes in the livers of Fpr2^-/- EtOH mi

SUBMITTER: Hardesty JE 

PROVIDER: S-EPMC11432144 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature