Interactions of SARS-CoV-2 with Human Target Cells-A Metabolic View.

ABSTRACT: Viruses are obligate intracellular parasites, and they exploit the cellular pathways and resources of their respective host cells to survive and successfully multiply. The strategies of viruses concerning how to take advantage of the metabolic capabilities of host cells for their own replication can vary considerably. The most common metabolic alterations triggered by viruses affect the central carbon metabolism of infected host cells, in particular glycolysis, the pentose phosphate pathway, and the tricarboxylic acid cycle. The upregulation of these processes is aimed to increase the supply of nucleotides, amino acids, and lipids since these metabolic products are crucial for efficient viral proliferation. In detail, however, this manipulation may affect multiple sites and regulatory mech

SUBMITTER: Eisenreich W 

PROVIDER: S-EPMC11432161 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature