Exploring Sex Differences in Pain Manifestation of Coronary Artery Disease through Mendelian Randomization.

ABSTRACT: Pain manifestation following coronary artery disease (CAD) disease differs between men and women. Here, we aimed to provide evidence favoring possible differences in pain manifestation between men and women following CAD using Mendelian randomization (MR). We used summary-level data from sex-stratified genome-wide association studies on CAD and self-reported and clinically diagnosed chest, neck and shoulder, back, and facial pain using data from the UK Biobank cohort (N > 450,000) followed by two-sample MR (sensitivity) analyses. We identified 32 and 19 independent genetic variants associated with CAD for men and women, respectively, as instrumental variables. Genetically influenced CAD was associated with a higher risk of self-reported chest pain in both men (OR: 1.27, CI: 1.2-1.33

SUBMITTER: Methorst R 

PROVIDER: S-EPMC11432350 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature