Candidate Genes Associated with Survival Following Highly Pathogenic Avian Influenza Infection in Chickens.

ABSTRACT: Highly pathogenic strains of avian influenza (HPAI) devastate poultry flocks and result in significant economic losses for farmers due to high mortality, reduced egg production, and mandated euthanization of infected flocks. Within recent years, HPAI outbreaks have affected egg production flocks across the world. The H5N2 outbreak in the US in 2015 resulted in over 99% mortality. Here, we analyze sequence data from chickens that survived (42 cases) along with uninfected controls (28 samples) to find genomic regions that differ between these two groups and that, therefore, may encompass prime candidates that are resistant to HPAI. Blood samples were obtained from survivors of the 2015 HPAI outbreak plus age and genetics-matched non-affected controls. A whole-genome sequence was obtained, an

SUBMITTER: Drobik-Czwarno W 

PROVIDER: S-EPMC11432379 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature