Deep Immune and RNA Profiling Revealed Distinct Circulating CD163+ Monocytes in Diabetes-Related Complications.

ABSTRACT: CD163, a scavenger receptor with anti-inflammatory function expressed exclusively on monocytes/macrophages, is dysregulated in cases of diabetes complications. This study aimed to characterize circulating CD163+ monocytes in the presence (D^+Comps) or absence (D^-Comps) of diabetes-related complications. RNA-sequencing and mass cytometry were conducted on CD163+ monocytes in adults with long-duration diabetes and D^+Comps or D^-Comps. Out of 10,868 differentially expressed genes identified between D^+Comps and D^-Comps, 885 were up-regulated and 190 were down-regulated with a ≥ 1.5-fold change. In D^+Comps, 'regulation of centrosome cycle' genes were enriched 6.7-fold compared to the reference genome. MIR27A, MIR3648-

SUBMITTER: Siwan E 

PROVIDER: S-EPMC11432403 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature