Dysbiosis in Human Urinary Microbiota May Differentiate Patients with a Bladder Cancer.

ABSTRACT: Recent interest in noninvasive diagnostic approaches has highlighted the potential of urinary microbiota as a novel biomarker for bladder cancer. This study investigated the urinary microbiota of 30 bladder cancer patients and 32 healthy controls using a specific NGS protocol that sequences eight hypervariable regions of the 16S rRNA gene, providing detailed insights into urinary microbiota composition. The relative abundance of microbial compositions in urine samples from cancer patients and healthy controls was analyzed across various taxonomic levels. No notable differences were highlighted at the phylum, class, order, and family levels. At the genus level, 53% of detected genera were represented in either cancer patients or healthy controls. Microbial diversity was significantly lower

SUBMITTER: Vendrell JA 

PROVIDER: S-EPMC11432408 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature