Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity.

ABSTRACT: Gallium-based therapy has been considered a potentially effective cancer therapy for decades and has recently re-emerged as a novel therapeutic strategy for the management of glioblastoma tumors. Gallium targets the iron-dependent phenotype associated with aggressive tumors by mimicking iron in circulation and gaining intracellular access through transferrin-receptor-mediated endocytosis. Mechanistically, it is believed that gallium inhibits critical iron-dependent enzymes like ribonucleotide reductase and NADH dehydrogenase (electron transport chain complex I) by replacing iron and removing the ability to transfer electrons through the protein secondary structure. However, information regarding the effects of gallium on cellular iron metabolism is limited. As mitochondrial iron metabolism

SUBMITTER: Owusu SB 

PROVIDER: S-EPMC11432413 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature