Bioinformatic Analysis of IKK Complex Genes Expression in Selected Gastrointestinal Cancers.

ABSTRACT: Gastrointestinal cancers account for over a quarter of all cancer cases and are associated with poor prognosis and high mortality rates. The IKK complex (the canonical I kappa B kinase), comprising the CHUK, IKBKB, and IKBKG genes, plays a crucial role in activating the NF-kB signaling pathway. This study aimed to analyze publicly available bioinformatics data to elucidate the oncogenic role of IKK genes in selected gastrointestinal cancers. Our findings reveal that IKBKB and IKBKG are significantly upregulated in all examined cancers, while CHUK is upregulated in esophageal carcinoma and stomach adenocarcinoma. Additionally, the expression of IKK genes varies with histological grade and nodal metastases. For instance, in stomach aden

SUBMITTER: Zebrowska-Nawrocka M 

PROVIDER: S-EPMC11432643 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature