Whole Mitochondrial Genome Sequencing Analysis of Canine Testicular Tumours.

ABSTRACT: Currently, the molecular background based on mitochondrial DNA (mtDNA) analysis of canine testicular tumours is underestimated. The available data mostly focus on histopathological evaluations, with a few reports of nuclear genome (nDNA) studies. Tumourigenesis represents a highly complex and diverse genetic disorder, which can also encompass defects in mtDNA. The aim of this study was to identify molecular changes in whole mitochondrial genome sequences obtained from dogs affected by testicular tumours. Samples of blood, tumour, and healthy tissue were collected from each animal, and mtDNA (ultimately 45 samples) was subsequently sequenced. Thereafter, protein analyses were performed to assess the impact of the identified molecular alterations on the amino acid level. The total number of

SUBMITTER: Tkaczyk-Wlizlo A 

PROVIDER: S-EPMC11432695 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature