Phenotypic and genotypic analysis of drug resistance in M. tuberculosis isolates in Gansu, China.

ABSTRACT: Tuberculosis has posed a serious threat to human health. It is imperative to investigate the geographic prevalence of tuberculosis and medication resistance, as this information is essential for informing strategies for its prevention and treatment. Drug resistance was identified using a proportion method. Drug-resistant genes and pathways were predicted using whole genome sequencing. The drug resistance range of bedaquiline was identified using the microporous plate two-fold dilution method, and drug resistance genes were studied using sequencing. The study revealed that 19.99% of the tuberculosis cases had multidrug resistance. The genes of M. tuberculosis are predominantly involved in the synthesis of ABC transporters, two-component systems, and bacterial secretion systems, as well as i

SUBMITTER: Peng Y 

PROVIDER: S-EPMC11432870 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature