Modelling the effects of 4-factor prothrombin complex concentrate for the management of factor Xa-associated bleeding.

ABSTRACT: The management of factor Xa (FXa) inhibitor-associated bleeding remains a clinical challenge. Massive bleeding is often associated with complex coagulopathy and, thus, the sole reversal of FXa inhibitors might not be sufficient to restore hemostasis, requiring instead a multimodal approach. Four-factor prothrombin complex concentrate (4F-PCC) is widely recognized as a viable treatment option for FXa inhibitor-associated bleeding. Here, we applied computational models to explore the effect 4F-PCC has on the coagulation cascade and restoration of thrombin generation in a system that simulates a patient that has received a FXa inhibitor. The coagulation model is largely based on a previously developed model with modifications incorporated from various other published sources. The model was ca

SUBMITTER: Muir I 

PROVIDER: S-EPMC11432878 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature