Genome-wide association study between SARS-CoV-2 single nucleotide polymorphisms and virus copies during infections.

ABSTRACT: Significant variations have been observed in viral copies generated during SARS-CoV-2 infections. However, the factors that impact viral copies and infection dynamics are not fully understood, and may be inherently dependent upon different viral and host factors. Here, we conducted virus whole genome sequencing and measured viral copies using RT-qPCR from 9,902 SARS-CoV-2 infections over a 2-year period to examine the impact of virus genetic variation on changes in viral copies adjusted for host age and vaccination status. Using a genome-wide association study (GWAS) approach, we identified multiple single-nucleotide polymorphisms (SNPs) corresponding to amino acid changes in the SARS-CoV-2 genome associated with variations in viral copies. We further applied a marginal epistasis test to d

SUBMITTER: Li K 

PROVIDER: S-EPMC11432881 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature