Arctigenin inhibits the progression of colorectal cancer through epithelial-mesenchymal transition via PI3K/Akt/mTOR signaling pathway.

ABSTRACT:

Background

Colorectal cancer (CRC) is a significant disease worldwide, with high mortality rates. Conventional treatment methods often lead to metastasis and drug resistance, highlighting the need to explore new drugs and their potential molecular mechanisms. In this study, we investigated the effects of arctigenin on CRC cell proliferation, migration, invasion, apoptosis, and related protein expression, as well as its potential molecular mechanisms.

Methods

The CCK-8 assay, transwell migration and invasion assays, flow cytometry, immunoblotting and immunofluorescence staining, western blot and an allograft tumor transplantation model was used.

Results

Our study revealed that arctigenin effectively inhibited CRC cell proliferation, migration, and invasion in a dose-de

SUBMITTER: Chen XF 

PROVIDER: S-EPMC11432899 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature