Plasma lipidome, circulating inflammatory proteins, and Parkinson's disease: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that plasma lipidome play a pivotal role in the occurrence of Parkinson's disease (PD). However, it remains unknown which lipids among plasma lipidome affect PD and how they exert their influence. Clarity is lacking regarding the causal relationship between plasma lipidome and PD, as well as whether circulating inflammatory proteins serve as mediators.

Methods

Single nucleotide polymorphisms (SNPs) significantly associated with 179 plasma lipidome were selected as instrumental variables to assess their causal impact on PD. PD data, serving as the outcome, were sourced from the International Parkinson's Disease Genomics Consortium, which boasts the largest sample size to date. The inverse variance weighted (IVW), Weighted median

SUBMITTER: Qin Y 

PROVIDER: S-EPMC11433008 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature