Trypsin and Trypsinogen Activation Peptide in the Prediction of Severity of Acute Pancreatitis.

ABSTRACT:

Objectives

To assess the predictive value of serum trypsin and trypsinogen activation peptide (TAP) for the severity of AP through a single center cohort study as well as a systematic review of the current literature.

Methods

A literature search was conducted using Medline (PubMed), EMBASE and the Cochrane Central Register. A total of 142 patients with acute pancreatitis (AP) were included in the cohort study and parameters of the revised Atlanta criteria of 2012 and the APACHE II were assessed.

Results

The review showed promising results for the predictive value of serum trypsinogen-2 but conflicting results for serum TAP and trypsin. In the cohort study, patients were observed for 4 days after diagnosis of AP; 9 patients had severe AP, 35 patients had moderate AP an

SUBMITTER: Allemann A 

PROVIDER: S-EPMC11433092 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature