Cost-utility analysis of proton beam therapy for locally advanced esophageal cancer in Japan.

ABSTRACT:

Purpose

Proton beam therapy (PBT) has recently been included in Japan's health insurance benefit package for certain cancer types. This study aimed to determine the cost-effectiveness of PBT as a replacement for conventional three-dimensional conformal radiotherapy (3D-CRT) for locally advanced esophageal cancer (LAEC) that is not covered by social insurance.

Methods

We estimated the incremental cost-effectiveness ratio (ICER) of PBT as a replacement for 3D-CRT, using clinical evidence from the literature and expert opinions. We used an economic model, decision tree, and Markov model to illustrate the courses followed by patients with LAEC. Effectiveness was estimated as quality-adjusted life years (QALY) using utility weights for the health state. Social insurance fees were

SUBMITTER: Sawada T 

PROVIDER: S-EPMC11433116 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature