Optimizing Piperacillin Dosing in Pediatric Liver Transplant Recipients: A Case Series.

ABSTRACT:

Background

Pathophysiological changes post-liver transplantation impact the pharmacokinetics and pharmacodynamics of antibiotics. Piperacillin, often used in combination with tazobactam, is a key antibiotic after transplantation to its broad-spectrum activity, but there is a lack of specific pharmacokinetic data in this population. This study aims to describe the pharmacokinetic parameters and target attainment of piperacillin in pediatric liver transplant recipients.

Methods

Patients with preserved renal function (estimated glomerular filtration rate > 50 mL/min/1.73 m²) receiving intravenous piperacillin-tazobactam at 112.5 mg/kg every 8 h (100 mg piperacillin/12.5 mg tazobactam), with a rapid infusion (0.5-1 h), were included. Two blood samples per child were c

SUBMITTER: Morales Junior R 

PROVIDER: S-EPMC11433544 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature