Axial O Atom-Modulated Fe(III)-N₄ Sites for Enhanced Cascade Catalytic ¹O₂-Induced Tumor Therapy.

ABSTRACT: The rational construction of efficient hypoxia-tolerant nanocatalysts capable of generating singlet oxygen (¹O₂) without external stimuli is of great importance for tumor therapy. Herein, uniformly dispersed and favorable biosafety profile graphitic carbon nitride quantum dots immobilized with Fe-N₄ moieties modulated by axial O atom (denoted as O-Fe-N₄) are developed for converting H₂O₂ into ¹O₂ via Russell reaction, without introducing external energy. Notably, O-Fe-N₄ performs two interconnected catalytic properties: glutathione oxidase-mimic activity to provide substrate for subsequent ¹O₂ generation, avoiding the blunting anticancer efficacy by glutathione. The O-Fe

SUBMITTER: Liu H 

PROVIDER: S-EPMC11434021 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature