Olea europaea L. Leaves as a Source of Anti-Glycation Compounds.

ABSTRACT: High concentrations of advanced glycation end products (AGEs) have been linked to diseases, including diabetic complications. The pathophysiological effects of AGEs are mainly due to oxidative stress and inflammatory processes. Among the proteins most affected by glycation are albumin, the most abundant circulating protein, and collagen, which has a long biological half-life and is abundant in the extracellular matrix. The potential cellular damage caused by AGEs underscores the importance of identifying and developing natural AGE inhibitors. Indeed, despite initial promise, many synthetic inhibitors have been withdrawn from clinical trials due to issues such as cytotoxicity and poor pharmacokinetics. In contrast, natural products have shown significant potential in inhibiting AGE formatio

SUBMITTER: Vasarri M 

PROVIDER: S-EPMC11434099 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature