On the Temporal Evolution of Key Hemofilter Parameters-In Vitro Study under Co-Current Flow.

ABSTRACT: Effective permeability K_P, the ultrafiltration coefficient (K_UF), the sieving coefficient (SC), and the loss/permeation of proteins (primarily albumin) are key parameters/specifications characterizing hemofilter (HF) performance. However, there are uncertainties regarding their determination. This work aims (a) to demonstrate that the co-current flow (of blood and dialysate) can lead to beneficial unidirectional filtration (from blood/plasma to dialysate) under a fairly uniform local trans-membrane pressure (TMP), unlike the presently employed counter-current flow; (b) to study the temporal evolution of key HF performance parameters under co-current flow, particularly during the important early stage of hemocatharsis (HC). Experiments with human plasma and BSA solutio

SUBMITTER: Karabelas AJ 

PROVIDER: S-EPMC11434192 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature