A Novel Bi-Directional Channel for Nutrient Uptake across Mycobacterial Outer Envelope.

ABSTRACT: Nutrients are absorbed by special transport proteins on the cell membrane; however, there is less information regarding transporters across the mycobacterial outer envelope, which comprises dense and intricate structures. In this study, we focus on the model organism Mycolicibacterium smegmatis, which has a cell envelope similar to that of Mycobacterium tuberculosis, as well as on the TiME protein secretion tube across the mycobacterial outer envelope. We present transcriptome results and analyze the protein compositions of a mycobacterial surface envelope, determining that more transporters and porins are induced to complement the deletion of the time gene in Mycolicibacterium smegmatis. The TiME protein is essential for nutrient utilization, as demonstrated in

SUBMITTER: Liu L 

PROVIDER: S-EPMC11434571 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature