Development of Resorbable Phosphate-Based Glass Microspheres as MRI Contrast Media Agents.

ABSTRACT: In this research, resorbable phosphate-based glass (PBG) compositions were developed using varying modifier oxides including iron (Fe₂O₃), copper (CuO), and manganese (MnO₂), and then processed via a rapid single-stage flame spheroidisation process to manufacture dense (i.e., solid) and highly porous microspheres. Solid (63-200 µm) and porous (100-200 µm) microspheres were produced and characterised via SEM, XRD, and EDX to investigate their surface topography, structural properties, and elemental distribution. Complementary NMR investigations revealed the formation of Q², Q¹, and Q⁰ phosphate species within the porous and solid microspheres, and degradation studies performed to evaluate mass loss, particle size, and pH chan

SUBMITTER: Molinar-Diaz J 

PROVIDER: S-EPMC11434598 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature