Comprehensive Genomic Analysis of Uropathogenic <i>E. coli</i>: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.

ABSTRACT: Our whole-genome sequencing analysis of sixteen uropathogenic E. coli isolates revealed a concerning picture of multidrug resistance and potentially virulent bacteria. All isolates belonged to four distinct clonal groups, with the highly prevalent ST131 lineage being associated with extensive antibiotic resistance and virulence factors. Notably, all isolates exhibited multidrug resistance, with some resistant to as many as 12 antibiotics. Fluoroquinolone resistance stemmed primarily from efflux pumps and mutations in gyrase and topoisomerase genes. Additionally, we identified genes encoding resistance to extended-spectrum cephalosporins, trimethoprim/sulfamethoxazole, and various heavy metals. The presence of diverse plasmids and phages suggests the potential for horizontal gene tra

SUBMITTER: Sung K 

PROVIDER: S-EPMC11434687 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature