Food Avoidance and Aversive Goal Value Computation in Anorexia Nervosa.

ABSTRACT: Anorexia nervosa (AN) is associated with food restriction and significantly low body weight, but the neurobiology of food avoidance in AN is unknown. Animal research suggests that food avoidance can be triggered by conditioned fear that engages the anterior cingulate and nucleus accumbens. We hypothesized that the neural activation during food avoidance in AN could be modeled based on aversive goal value processing. Nineteen females with AN and thirty healthy controls matched for age underwent functional magnetic resonance brain imaging while conducting a food avoidance task. During active control free-bid and computer-generated forced-bid trials, participants bid money to avoid eating food items. Brain activation was parametrically modulated with the trial-by-trial placed bids. During fre

SUBMITTER: Weider S 

PROVIDER: S-EPMC11434691 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature