Evaluating Atlantic Salmon (<i>Salmo salar</i>) as a Natural or Alternative Host for Piscine Myocarditis Virus (PMCV) Infection.

ABSTRACT: Cardiomyopathy syndrome (CMS) caused by piscine myocarditis virus (PMCV) has emerged with the rise of the aquaculture of Atlantic salmon (Salmo salar). The lack of cell culture cultivation has hampered the study of this infection. In this study, samples from naturally PMCV-infected Atlantic salmon from different commercial farms were collected and used. In situ hybridization (ISH) revealed intense staining of PMCV RNA in myocardial cells in the spongiform layer of the heart ventricle but almost no staining in the compact layer. In the kidneys, only sporadic staining was seen. Viral RNA was present in all organs, with the highest loads in the heart, kidney, and spleen. The high viral PMCV RNA loads in the heart were due to extensive viral mRNA transcription. The high ratio of viral m

SUBMITTER: Nyman IB 

PROVIDER: S-EPMC11434702 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature