In Vitro Interaction of Binuclear Copper Complexes with Liver Drug-Metabolizing Cytochromes P450.

ABSTRACT: Two copper(II) mixed ligand complexes with dicarboxylate bridges were prepared and studied, namely [Cu₂(μ-fu)(pmdien)₂(H₂O)₂](ClO₄)₂ (complex No. 5) and [Cu₂(μ-dtdp)(pmdien)₂(H₂O)₂](ClO₄)₂ (complex No. 6), where H₂fu = fumaric acid, pmdien = N,N,N',N″,N″ pentamethyldiethylenetriamine, and H₂dtdp = 3,3'-dithiodipropionic acid. The copper atoms are coordinated in the same mode by the tridentate pmdien ligand and oxygen of water molecules, and they only differ in the dicarboxylate bridge. This work is focused on the study of the inhibitory effect of these potential antimicrobial drugs on the activity of the most important human liver

SUBMITTER: Spicakova A 

PROVIDER: S-EPMC11434749 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature