<i>Akkermansia muciniphila</i> as a Potential Guardian against Oral Health Diseases: A Narrative Review.

ABSTRACT: The oral microbiome is a diverse ecosystem containing a community of symbiotic, commensal, and pathogenic microorganisms. One key microorganism linked to periodontal disease (PD) is Porphyromonas gingivalis (P. gingivalis), a Gram-negative anaerobic bacterium known to have several virulence factors that trigger inflammation and immune evasion. On the other hand, Akkermansia muciniphila (A. muciniphila), a symbiotic bacterium, has been recently shown to play an important role in mitigating inflammation and reducing periodontal damage. In vivo and in vitro studies have shown that A. muciniphila decreases inflammatory mediators and improves immune responses, suggesting its role in mitigating PD and related inflammatory systemic conditions such as diabetes, h

SUBMITTER: Anderson MH 

PROVIDER: S-EPMC11434887 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature