Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies.

ABSTRACT:

Background

Breast cancer therapy has been facing remarkable changes. Classic treatments are now combined with other therapies to improve efficacy and surpass resistance. Indeed, the emergence of resistance demands the development of novel therapeutic approaches. Due to key estrogen signaling, estrogen receptor-positive (ER⁺) breast cancer treatment has always been focused on aromatase inhibition and ER modulation. Lately, the effects of phytocannabinoids, mainly Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD), have been evaluated in different cancers, including breast. However, Cannabis sativa contains more than 120 phytocannabinoids less researched and understood.

Methods

Here, we evaluated, both in silico and in vitro, the ability of 129 ph

SUBMITTER: Almeida CF 

PROVIDER: S-EPMC11434916 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature