Genetic Diversity, Virulence, and Antibiotic Resistance Determinants of <i>Campylobacter jejuni</i> Isolates in Romania.

ABSTRACT: The emergence of antibiotic-resistant Campylobacter jejuni, a leading cause of gastroenteritis worldwide, presents a significant public health challenge requiring vigilant surveillance and disease control. This study aimed to characterize C. jejuni strains isolated in Romania from 2017 to 2020, focusing on genetic diversity, virulence, and antibiotic resistance determinants. The isolates underwent phenotypical testing, PCR, and antibiotic resistance assessment using the Kirby-Bauer disc diffusion method for ciprofloxacin, erythromycin, and tetracycline. Genetic analysis identified resistance and virulence genes, point mutations, and performed sequence typing (7-gene MLST) to determine genetic relatedness. Results indicated substitutions at position 86 in the amino acid sequen

SUBMITTER: Baltoiu M 

PROVIDER: S-EPMC11434920 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature