Differential Drug Susceptibility across Trichomonasvirus Species Allows for Generation of Varied Isogenic Clones of <i>Trichomonas vaginalis</i>.

ABSTRACT: Trichomonas vaginalis (Tvag) is a sexually transmitted human pathogen that is commonly infected with strains of one or more of five known species of Trichomonas vaginalis viruses (TVVs), members of genus Trichomonasvirus. TVVs are thought not to have an extracellular phase to their lifecycle and instead to be transmitted vertically from mother to daughter cells. As a result, generation of isogenic virus-positive and virus-negative sets of Tvag clones has been a major barrier to studying interactions between TVVs and their host. Nucleoside analog 2'-C-methylcytidine (2CMC) has been recently reported to clear trichomonads of infections with TVV1, TVV2, and TVV3. We used 2CMC to treat a panel of Tvag isolates that collectively harbor at least one representative strain of each TV

SUBMITTER: Hetzel CA 

PROVIDER: S-EPMC11434947 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature