Filbertone Reduces Senescence in C₂C₁₂ Myotubes Treated with Doxorubicin or H₂O₂ through MuRF1 and Myogenin.

ABSTRACT: It has been demonstrated that filbertone, the principal flavor compound of hazelnuts, exhibits preventive effects against hypothalamic inflammation, obesity, neurodegenerative diseases, and muscle lipid accumulation. However, its influence on muscle aging has yet to be elucidated. The objective of this study was to investigate the effects of filbertone on muscle aging in C₂C₁₂ myotubes subjected to senescence induction by either doxorubicin or hydrogen peroxide. To ascertain the mechanisms by which filbertone exerts its effects, we conducted a series of experiments, including Western blot analysis, reverse transcription quantitative polymerase chain reaction (qRT-PCR), and senescence-associated β-galactosidase (SA-β-gal) staining. Filbertone was markedly observed to d

SUBMITTER: Jung S 

PROVIDER: S-EPMC11434963 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature