Deciphering Chemical Rules for Drug Penetration into Strongyloides.

ABSTRACT: Background: Strongyloidiasis, a parasitic infection, presents a significant public health challenge in tropical regions due to the limited repertoire of effective treatments. The screening of chemical libraries against the therapeutically relevant third-stage larvae (L3) of the model parasite Strongyloides venezuelensis yielded meager success rates. This situation is reminiscent of Gram-negative bacteria, where drug entry is a limiting factor. Methods: Here, we set out to determine whether similar barriers are in place and establish whether structural and property requirements exist for anti-strongyloides drug discovery. We focused on dyes as their uptake and effects on viability can be independently assessed in the multicellular parasite, thus providing a means to stu

SUBMITTER: Marin M 

PROVIDER: S-EPMC11434980 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature