Generational Diet-Induced Obesity Remodels the Omental Adipose Proteome in Female Mice.

ABSTRACT: Obesity, a complex condition that involves genetic, environmental, and behavioral factors, is a non-infectious pandemic that affects over 650 million adults worldwide with a rapidly growing prevalence. A major contributor is the consumption of high-fat diets, an increasingly common feature of modern diets. Maternal obesity results in an increased risk of offspring developing obesity and related health problems; however, the impact of maternal diet on the adipose tissue composition of offspring has not been evaluated. Here, we designed a generational diet-induced obesity study in female C57BL/6 mice that included maternal cohorts and their female offspring fed either a control diet (10% fat) or a high-fat diet (45% fat) and examined the visceral adipose proteome. Solubilizing proteins from

SUBMITTER: Schuster-Little N 

PROVIDER: S-EPMC11435095 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature