Comparative Assessment of Beeswax Alcohol and Coenzyme Q₁₀ (CoQ₁₀) to Prevent Liver Aging, Organ Damage, and Oxidative Stress in Hyperlipidemic Zebrafish Exposed to D-Galactose: A 12-Week Dietary Intervention.

ABSTRACT: The current study was designed to compare in vivo efficacy between beeswax alcohol (BWA) and coenzyme Q₁₀ (CoQ₁₀) to treat fatty liver changes, oxidative stress, and damages in major organs of zebrafish by 12 weeks with high-cholesterol (HC) and galactose (Gal) supplementation. At week 12, the HC control and HC+Gal control groups showed 96% and 92% survivability, respectively, while co-supplementation of the 0.5% BWA and 1.0% BWA groups exhibited 96% and 100% survivability. However, co-supplementation of the 0.5% CoQ₁₀ and 1.0% CoQ₁₀ groups revealed the lowest survivability, around 92% and 89%, respectively. The 0.5% BWA and 1.0% BWA groups showed 21% (p < 0.001) and 41% (p < 0.001), respectively, lower total cholesterol (TC) than t

SUBMITTER: Cho KH 

PROVIDER: S-EPMC11435097 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature