Licorice Extract Isoliquiritigenin Protects Endothelial Function in Type 2 Diabetic Mice.

ABSTRACT: Endothelial dysfunction occurs prior to atherosclerosis, which is an independent predictor of cardiovascular diseases (CVDs). Diabetes mellitus impairs endothelial function by triggering oxidative stress and inflammation in vascular tissues. Isoliquiritigenin (ISL), one of the major bioactive ingredients extracted from licorice, has been reported to inhibit inflammation and oxidative stress. However, the therapeutic effects of ISL on ameliorating type 2 diabetes (T2D)-associated endothelial dysfunction remain unknown. In our animal study, db/db male mice were utilized as a model for T2D-associated endothelial dysfunction, while their counterpart, heterozygote db/m⁺ male mice, served as the control. Mouse brain microvascular endothelial cells (mBMECs)

SUBMITTER: Wang L 

PROVIDER: S-EPMC11435099 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature