Anticancer Activity of Imidazolyl Gold(I/III) Compounds in Non-Small Cell Lung Cancer Cell Lines.

ABSTRACT: Lung cancer is a leading cause of cancer-related death worldwide that needs updated therapies to contrast both the serious side effects and the occurrence of drug resistance. A panel of non-small cell lung cancer (NSCLC) cells were herein employed as cancer models. Eight structurally related gold(I) and gold(III) complexes with NHC and halides or triphenylphosphane ligands were investigated as lung cancer cell growth inhibitors. As expected, gold compounds with PPh₃ were found to be more cytotoxic than homoleptic [(NHC)₂-Au(I)]X or heteroleptic NHC-Au(I)X or NHC-Au(III)X₃ complexes. Mixed ligand gold(I) compounds exhibiting the linear NHC-AuPPh₃ (compound 7) or the trigonal NHC-Au(Cl)PPh₃ (compound 8) arrangements at the

SUBMITTER: Galassi R 

PROVIDER: S-EPMC11435220 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature