Efficacy and Safety of Poly-l-Lactic Acid in Facial Aesthetics: A Systematic Review.

ABSTRACT: The primary objective of this systematic review study was to investigate the effectiveness, durability, and adverse events of PLLA treatment for aesthetic indications. The search strategy was performed in MEDLINE (Ovid). The electronic literature search of five databases was performed, from the inception of the databases until the 12th of February 2024. This was to identify randomized clinical trials that assessed PLLA treatment in adult individuals exhibiting facial aging and/or facial lipoatrophy. Risk of bias was assessed using the Cochrane Risk-of-Bias Tool for Randomized Trials (RoB 2). Eleven RCTs out of 1467 identified citations were included. Four studies showed increased dermal thickness, significant improvement in facial lipoatrophy severity and aesthetic clinical scores, after P

SUBMITTER: Signori R 

PROVIDER: S-EPMC11435306 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature